RISE OVERVIEW
The RISE Consortium is a NICHD-funded U19 program involving a multi-country research collaboration among multiple experienced research groups focused on improving outcomes of CHEU (children HIV-exposed and uninfected) in high HIV prevalence settings, Botswana, Kenya and Zimbabwe. The RISE Consortium was designed to move beyond observational studies and identify interventions, optimize their implementation, and refine surveillance strategies to address the needs of CHEU in high HIV prevalence settings.
The RISE Consortium is comprised of three research projects:
Project 1 (IMAGE) aims to determine associations between neuroanatomic pathways and neurodevelopment using magnetic resonance imaging (MRI) among CHEU in Botswana and Kenya
Project 2 (BONDS) aims to test a holistic intervention to improve neurodevelopment in a 3-country randomized controlled trial (RCT) in Botswana, Kenya and Zimbabwe
Project 3 (IMPLEMENT) aims to conduct modelling and piloting of implementation strategies to optimize scale-up of interventions either universally or in a risk-stratified approach among CHEU in Botswana, Kenya and Zimbabwe
Coherence between the projects and across countries is facilitated by three strategic Cores:
Data Management and Analysis Core (DMAC), overseeing data management and analysis
Scientific Administrative Core (SAC), overseeing scientific, administrative, fiscal, and communication components
Dissemination and Engagement Core (DEC), coordinating efforts to promptly and widely disseminate findings to facilitate translation to policy and public health impact
The RISE Multiple Principal Investigators bring decades of experience in CHEU research and leading long-standing research collaborations with communities in Zimbabwe, Botswana, and Kenya.
Andrew Prendergast, MA, DPhil, MRCPCH, DTM&H
Professor
Paediatric Infection & Immunology
Queen Mary University of London
Director
Zvitambo Institute for Maternal and Children Health Research
Kate Powis, MD
Internist and Pediatrician
Massachusetts General Hospital
Associate Professor
Department of Pediatrics
Harvard Medical School
Research Associate
Department of Immunology and Infectious Diseases
Harvard School of Public Health
Principal Investigator
Botswana Harvard Public Health Partnership
Grace John-Stewart, MD, PhD
Professor
Global Health, Medicine, Epidemiology, and Pediatrics
University of Washington (UW)
Founding Director
UW Center for Global Health of Women, Adolescents, and Children
Associate Director
UW/Fred Hutch Center for AIDS Research
Dalton Wamalwa, MBChB, MMed, MPH
Associate Professor
Department of Paediatrics and Child Health
University of Nairobi
