RISE OVERVIEW
The RISE Consortium is a NICHD-funded U19 program involving a multi-country research collaboration among multiple experienced research groups focused on improving outcomes of CHEU (children HIV-exposed and uninfected) in high HIV prevalence settings, Botswana, Kenya and Zimbabwe. The RISE Consortium was designed to move beyond observational studies and identify interventions, optimize their implementation, and refine surveillance strategies to address the needs of CHEU in high HIV prevalence settings.
The RISE Consortium is comprised of three research projects:
Project 1 (IMAGE) aims to determine associations between neuroanatomic pathways and neurodevelopment using magnetic resonance imaging (MRI) among CHEU in Botswana and Kenya
Project 2 (BONDS) aims to test a holistic intervention to improve neurodevelopment in a 3-country randomized controlled trial (RCT) in Botswana, Kenya and Zimbabwe
Project 3 (IMPLEMENT) aims to conduct modelling and piloting of implementation strategies to optimize scale-up of interventions either universally or in a risk-stratified approach among CHEU in Botswana, Kenya and Zimbabwe
Coherence between the projects and across countries is facilitated by three strategic Cores:
Data Management and Analysis Core (DMAC), overseeing data management and analysis
Scientific Administrative Core (SAC), overseeing scientific, administrative, fiscal, and communication components
Dissemination and Engagement Core (DEC), coordinating efforts to promptly and widely disseminate findings to facilitate translation to policy and public health impact
The RISE Multiple Principal Investigators bring decades of experience in CHEU research and leading long-standing research collaborations with communities in Zimbabwe, Botswana, and Kenya.
Andrew Prendergast, MA, DPhil, MRCPCH, DTM&H
Professor of Paediatric Infection & Immunology at Queen Mary University of London
Director of the Zvitambo Institute for Maternal and Children Health Research
Wellcome Trust Senior Clinical Fellow
Kate Powis, MD
Associate Professor at Mass General Research Institute
Associate Professor of Pediatrics at Harvard Medical School
Research Associate in the Department of Immunology and Infectious Diseases, Harvard School of Public Health
Grace John-Stewart, MD, PhD
Professor of Global Health, Medicine, Epidemiology, and Pediatrics at the University of Washington (UW)
Co-Director of the UW Center for Global Health of Women, Adolescents, and Children (UW Global WACh)
Associate Director of UW/Fred Hutch Center for AIDS Research (CFAR), and a member of the Kenya Research and Training Center (KRTC)
Dalton Wamalwa, MBChB, MMed, MPH
Lecturer and Associate Professor and Chair of the Department of Paediatrics and Child Health at the University of Nairobi.
Member of the National AIDS and STI Control Program (NASCOP) Technical working group on paediatric care and treatment
Rise Consortium 